Welcome to the Epigenome and Genome Integrity Lab (EaGIL)

We are a multidisciplinary research lab focused on understanding how chromatin dynamics and genome stability are maintained in healthy cells and how their disruption contributes to cancer. Our work centers on decoding the epigenetic and genetic mechanisms that regulate key cellular processes such as DNA replication, transcription, RNA processing, and the DNA damage response. By combining molecular biology, functional genomics, proteomics, and computational biology, we aim to uncover fundamental insights with direct translational relevance.We are a multidisciplinary research lab exploring how cells maintain chromatin structure and genome stability, and how failures in these systems can lead to cancer. Our work focuses on the molecular mechanisms behind DNA replication, transcription, RNA processing, and the DNA damage response.
We study how replication stress and chromatin regulators like SET8 protect the genome, and how their disruption contributes to genomic instability. A key area of interest is histone mRNA regulation specifically, how the loss of their normal stem-loop structure and gain of a poly A tail in cancer may promote disease. Our research spans epigenetic control, RNA modifications, and receptor-based drug delivery, with a growing focus on patient-derived cancer models to support personalized treatment approaches.
We also build innovative tools like nanoTag-seq to track protein-DNA interactions and CAS-qPCR to assess the impact of cancer-specific mutations. By combining molecular biology, genomics, proteomics, and bioinformatics, we aim to uncover core principles of genome regulation and contribute new knowledge to cancer biology and therapy.