We aim to characterize chromatin-centered molecular pathways that govern key cellular processes including DNA replication, transcription, and DNA damage response. Our work employs a combination of conventional molecular & cellular biology techniques, high-throughput genomics & proteomics technologies such as ChIPseq, RNAseq, ATAC-seq, and Mass Spec as well as bioinformatics analysis to decode the complex underpinnings of the aforementioned cellular processes. We are keen on integrating the high throughput biological data acquired from these methods to build next-generation multiscale in silico networks of epigenetic and DNA damage response factors. Using Systems Biology approaches, we annotate biomolecular networks with patient-specific mutations and gene expression data and develop next-generation precision cancer therapies.