Research Publications
Basic Sciences
- Shoaib M*‡, Boukoura S‡, Saint-Ruf C‡, Walter D, Dulina E, Larsen DH, Miotto B, Sørensen CS *. SET8 safeguards genome stability by regulating replication fork speed and suppressing excessive nuclease processing. (in preparation) (*Co-corresponding author) (‡ Equal contribution)
- Maynard S, Hall A, Galanos P, Rizza S, Yamamoto T, Gram HH, Munk SHN, Shoaib M, Sørensen CS, Bohr VA, Lerdrup M, Maya-Mendoza A, Bartek J. Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway. Nucleic Acids Res. 2022 Sep 23;50(17):9948-9965. doi: https://doi.org/10.1093/nar/gkac741
- Shoaib M*, Chen Q*, Shi X, Nair N, Prasanna C, Yang R, Walter D, Frederiksen KS, Einarsson H, Svensson JP, Liu CF, Ekwall K, Lerdrup M, Nordenskiöld L, Sørensen CS. Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes. Nat Commun. 2021 Aug 20;12(1):4800 (*Equal contribution) doi: https://doi.org/10.1038/s41467-021-25051-2
- Shoaib M*, Nair N*, Sorensen CS. Chromatin Landscaping At Mitotic Exit Orchestrates Genome Function. Front Genet. 2020; 11:103. (* Equal contribution) doi: https://doi.org/10.3389/fgene.2020.00103/full
- Parveen A, Khan SA, Mirza MU, Bashir H, Arshad F, Iqbal M, Ahmad W, Wahab A, Fayyaz A, Naz S, Ashraf F, Mobeen T, Aziz S, Ahmad SS, Muhammad N, Hassib NF, Mostafa MI, Gaboon NE, Gul R, Khan SU, Froeyen M, Shoaib M, Wasif N. Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: Interpretations from Molecular Dynamic Simulations. Int J Mol Sci. 2019 Oct 24;20(21). pii: E5282. doi: https://doi.org/10.3390/ijms20215282
- Jurisic, A., Robin, C., Tarlykov, P., Siggens, L., Schoell, B., Jauch, A., Ekwall, K., Sørensen, C. S., Lipinski, M., Shoaib, M.*, and Ogryzko, V. (2018). Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains. Nucleic Acids Res. 2018 Dec 14;46(22) (*Corresponding author) doi: https://doi.org/10.1093/nar/gky818
- Shoaib, M., Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, M., Johansen, J. V., Hansen, K., Julien, E., Blow, J. J., and Sørensen, C. S. Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing. Nat Commun. 2018 Sep 12;9(1):3704. doi: https://doi.org/10.1038/s41467-018-06066-8
- Hanif, M. U., Yaseen, A., Gul, R., Mirza, M. U., Nawaz, M. H., Ahmed, S. S., Aziz, S., Chaudhary, S., Khan, A. A., and Shoaib, M. (2018). Small Ubiquitin-Like Modifier Protein 3 Enhances the Solubilization of Human Bone Morphogenetic Protein 2 in E. coli. Appl Biochem Biotechnol. 2018 Sep;186(1):256-270. doi: https://doi.org/10.1007/s12010-018-2736-0
- Shoaib, M., and Sørensen, C.S. Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave. Cancer Cell. 2015;28, 545-547. doi: https://doi.org/10.1016/j.ccell.2015.10.009
- Shoaib M, Kulyyassov A, Robin C, Winczura K, Tarlykov P, Despras E, Kannouche P, Ramanculov E, Lipinski M, Ogryzko V. 2013. PUB-NChIP – In vivo biotinylation approach to study chromatin in proximity of a protein of interest. Genome Res. 2013 Feb; 23(2): 331-40). doi: https://doi.org/10.1101/gr.134874.111
- Kulyyassov A, Shoaib M, Pichugin A, Ramankulov E, Lipinski M, Ogryzko V. PUB-MS – A mass spectrometry-based method to monitor protein-protein proximity in-vivo. Journal of Proteome Research. 2011 Oct 7;10(10):4416-27. doi: https://doi.org/10.1021/pr200189p
- Kulyyassov A, Shoaib M, Ogryzko V. Use of in-vivo biotinylation for chromatin immunopreceipitation. Curr Protoc Cell Biol. 2011 Jun; Chapter 17: Unit17.12. doi: https://doi.org/10.1002/0471143030.cb1712s51
- Shoaib M., Baconnais S., Mechold U., Le Cam. E., Lipinski M., and Ogryzko V. Multiple displacement amplification for complex mixtures of DNA fragments. BMC. Genomics 2008;9: 415. doi: https:/doi.org/10.1186/1471-2164-9-415
- Sardar, U., Ali, S., Ayub, M. S., Shoaib, M., Bashir, K., Khan, I. U., & Patterson, M. (2023, October). Sequence-based nanobody-antigen binding prediction. In International Symposium on Bioinformatics Research and Applications (pp. 227-240). Singapore: Springer Nature Singapore.
- Nair, N.*, Shoaib, M*. and Sørensen, C.S. Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair. International Journal of Molecular Sciences. 2017 July 10; 18(7).
(*Equal contribution)
Clinical Sciences
- Butt, R.N., Amina, B., Sultan, M.U., Tanveer, Z.B., Gondal, M.N., Hussain, R., Khan, S., Akbar, R., Nasir, Z., Khalid, M.F., Khan, A.A.C., Faisal, A., Shoaib, M., Chaudhary, S.U. CanSeer: a translational methodology for developing personalized cancer models and therapeutics. Scientific Reports. https://www.nature.com/articles/s41598-025-99219-x
- Waqqar, S., Aziz, S., Shakeel, R., Waheed, A., Ahmed, S. S., Ali, A., Khan, A. A., and Shoaib, M*. Redox imbalance correlates with high Nugent score in bacterial vaginosis. J Obstet Gynaecol Res. 2018 Mar;44(3):509-517. (*Corresponding author) doi: https://doi.org/10.1111/jog.13543
- Aziz, S., Ahmed, S.S., Ali, A., Khan, F.A., Zulfiqar, G., Iqbal, J., Khan, A.A., and Shoaib, M*. Salivary Immunosuppressive Cytokines IL-10 and IL-13 Are Significantly Elevated in Oral Squamous Cell Carcinoma Patients. Cancer Investigation 2015; 33(7):318-28. (*Corresponding author) doi: https://doi.org/10.3109/07357907.2015.1041642
- Shoaib M*, Yazdanie N, Khan A. A, Hafeez O, Ibrahim N, and Azad B. Oral hygiene status and behaviour of the special needs children in Lahore, Pakistan. J Disability and Oral Health; 2006; 7(1) 43-47. (*Corresponding author)
- Shoaib M*, Baig MJ, Yazdanie N, Iqbal S, Kazmi F, and Khan A.A. Oral hygiene status & Brushing Practices of Individuals with Sensory and Physical Disabilities in Lahore, Pakistan. Jrnl. Pak. Dent. Assoc. 2004; Vol. 13 No. 4; Oct-Dec; p 189-197 (*Corresponding author)