Research interests
Sonia Abdullah Khan, an MS student, investigated the role of SET8 in the transcriptional regulation of DNA damage response (DDR) genes. Through RNA-seq analysis of SET8 knockdown cells, she observed consistent downregulation of key repair and chromatin-related genes such as MORF4L1, RBBP8, and HMGB2. Her findings, further validated by qRT-PCR, suggest that SET8 influences DDR gene expression, particularly in the double-strand break repair pathway, through an H4K20me1-dependent mechanism. This highlights SET8’s role in maintaining genomic stability at the transcriptional level.
Keywords
SET8, transcriptional regulation, DNA damage response (DDR)